Affiliation:
1. Translational Medicine Research Institute, First People’s Hospital of Foshan, Guangdong 528000, China
2. School of
Mathematics and Big Data, Foshan University, Guangdong 528000, China
Abstract
Background:
Osteoporosis has become a global public health problem, and Pueraria Lobata
(PL) is a potential drug for treating osteoporosis.
Methods:
Firstly, the components of PL were detected and identified based on UHPLC-Q-Exactive
Orbitrap MS. In addition, we used network pharmacology to study the potential mechanism of PL in
treating osteoporosis.
Result:
A total of 48 compounds, including 38 isoflavones, 6 puerosides, and 4 others, were identified
by UHPLC-Q Exactive-Orbitrap MS. The network of the pharmacological analysis revealed
that 28 compounds of PL regulated 19 pathways through 27 targets, including estrogen signaling
pathway and NF-kappa B signaling pathway, etc.
Conclusion:
This study used LC-MS combined with network pharmacology to identify the compounds
of PL and their mechanism of intervention in osteoporosis, which provides a scientific basis
for PL to become a functional food for preventing osteoporosis.
Publisher
Bentham Science Publishers Ltd.