Affiliation:
1. Institute of Pharmaceutical Research, GLA University, 17km Stone, NH-2, Mathura-Delhi Road Mathura, Chaumuhan,
Uttar Pradesh- 281406, India
Abstract
Chlorogenic acid (CHA) is a phenolic substance found in various edible plants, such
as tea and green coffee extracts. This chemical has demonstrated significant efficacy in reducing
the probability of many diseases in preclinical and clinical environments. Chlorogenic acid
(CHA) possesses several pharmacological attributes, such as anticancer, hepatoprotective, antimicrobial,
immune-suppressant, antioxidant, and antidiabetic activities. Its applications extend to
multiple industries, such as food, chemicals, medicine, and healthcare. Studies have shown that
CHA can exert its anticancer effects through numerous mechanisms. It can hinder the process of
cell division, trigger cell apoptosis, and suppress an increase in cancerous cell growth. The literature
research conducted for this study revealed a variety of molecular and cellular processes influencing
distinct signaling pathways. These mechanisms include angiogenesis, invasion and migration,
oxidative stress, inflammation, cell cycle arrest, and proliferation.However, significant
issues surround the use of CHA, primarily due to its limited bioavailability in animal models.
This review focuses on the chemistry, natural sources, pharmacokinetics, and underlying mechanisms
of action of CHA and its clinical utility in treating life-threatening diseases, such as cancer.
The manuscript provides insight into novel formulation approaches.
Publisher
Bentham Science Publishers Ltd.