Affiliation:
1. Department of Reproduction Center, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China
Abstract
Background:
Alzheimer’s Disease (AD) is a highly prevalent form of age-related
dementia. However, the underlying mechanisms of AD are largely unexplored.
Materials and Methods:
In this study, bioinformatics analysis was performed to identify the
possible therapeutic targets for AD. The GEO database was used to screen the Differentially
Expressed Genes (DEGs). Enrichment analysis, protein-protein interaction network, and LASSO
model analyses were successfully performed. Furthermore, an ELISA assay was also conducted
to determine the expression of principal genes within the AD and control samples.
Results:
A total of 416 differentially expressed genes (DEGs) were recognized based on the
GSE48350 and GSE28146 datasets. The IL-1β and CXCR4 levels were markedly elevated in
the AD samples relative to the control.
Conclusion:
The IL-1β and CXCR4 genes were identified as principal AD-related genes that
can be targeted for anti-AD therapy.
Publisher
Bentham Science Publishers Ltd.