Potential Links between ANRIL and MiRNAs in Various Cancers-Reference-Cited by-同舟云学术

Potential Links between ANRIL and MiRNAs in Various Cancers

Published:2024-06-07 Issue: Volume:27 Page:
ISSN:1386-2073
Container-title:Combinatorial Chemistry & High Throughput Screening
language:en
Short-container-title:CCHTS

Author:

Yang Xiaoyan¹²,Wei Liushan¹,Wu Shijie¹,Xie Zhizhong¹²,Lei Xiaoyong¹²

Affiliation:

1. School of Pharmaceutical Science, Hengyang Medical College, University of South China, 28 Western Changsheng Road, Hengyang, Hunan 421001, People's Republic of China

2. Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, 28 Western Changsheng Road, Hengyang, Hunan 421001, People's Republic of China

Abstract

Abstract: Non-coding RNAs are mainly divided into two categories: small non-coding RNA represented by miRNA, and the other is long non-coding RNA longer than 200 bp. Further studies on non-coding RNAs have revealed that long non-coding RNAs not only have carcinogenic effects but also have potential links with miRNAs. Antisense non-coding RNA in the INK4 locus (ANRIL/CDKN2B-AS1), one of the five subtypes of long non-coding RNA, has been proven to play the role of an oncogene in many cancers, such as gastric cancer, cervical cancer, prostate cancer, and non-small cell lung cancer. Knockdown ANRIL can significantly inhibit the proliferation and migration of cancer cells while also negatively regulating the expression of related miRNAs. This suggests that ANRIL may serve as a potential target for the development of drugs that provide new strategies to improve the effectiveness of cancer treatment. In our review, we summarize the current association between ANRIL and miRNAs in various cancers.

Publisher

Bentham Science Publishers Ltd.