Domino Liver Transplantation: Where are we Now?

Author:

Santopaolo Francesco1,Lenci Ilaria1,Bosa Alessandra1,Angelico Mario1,Milana Martina1,Baiocchi Leonardo1

Affiliation:

1. Unita Operativa di Epatologia, Policlinico Universitario di "Tor Vergata"; Viale Oxford 81, 00133 Rome, Italy

Abstract

Background:Domino transplant occurs when a recipient explanted graft is used for a second recipient.Introduction:The first experience came from thoracic surgery by the observation that many patients during heart-lung transplantation actually showed a functional heart that could be employed in other subjects with a good result.Results:This concept was then extended to the field of liver transplantation. At present, some patients transplanted for an inborn metabolic disease may be considered as excellent domino liver donors.Conclusion:The results, limitations, clinical challenges and the donor and recipient features of domino liver transplantation are discussed in this manuscript.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,General Medicine

Reference61 articles.

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2. Moini M.; Mistry P.; Schilsky M.L.; Liver transplantation for inherited metabolic disorders of the liver. Curr Opin Organ Transplant 2010,15,269-276

3. Hemming A.W.; Cattral M.S.; Greig P.D.; Domino liver transplantation for familial amyloid polyneuropathy: optimal use of a scarce resource. Transplant Proc 1999,31,515

4. Furtado A.J.L.; Domino liver transplantation using livers from patients with familial amyloidotic polyneuropathy. Curr Opin Organ Transplant 2000,5,69-73

5. Familial Amyloidotic Polyneuropathy World Transplant registry and Domino Liver Transplant Registry. Available from ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.fapwtr.org/">http: //www.fapwtr.org/

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