Satisfaction with Social Roles and Physical Function in Immune-mediated Inflammatory Diseases: A Cross-Sectional Study

Author:

Spagnuolo Rocco1ORCID,Iaquinta Francesco Salvatore2ORCID,Mauro Daniele3ORCID,Pantano Ilenia3,Dastoli Stefano2ORCID,Naty Saverio2,Cosco Cristina4,Mancina Rosellina Margherita5ORCID,Iacono Daniela3,Gaggiano Emanuela3,Ruggiero Annarita3,Nisticò Steven Paul2,Ciccia Francesco3ORCID,Grembiale Rosa Daniela3ORCID,Patrizia Doldo1

Affiliation:

1. Department of Clinical and Experimental Medicine, Magna Graecia University of Catanzaro, Calabria, Catanzaro, Italy

2. Department of Health Sciences, Magna Graecia University of Catanzaro, Calabria, Catanzaro, Italy

3. Dipartimento di Medicina di Precisione, Università della Campania L. Vanvitelli, Naples, Italy

4. Department of Clinical and Experimental Medicine, Magna Graecia University of Catanzaro, Calabria, Catanzaro, Italy

5. Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden

Abstract

Background: Although mood disorders have been well characterized by immune-mediated inflammatory diseases, physical function and satisfaction with social roles have not yet been defined as independent domains. Objective: The study aims to assess satisfaction with social roles and physical function alterations in a population with immune-mediated inflammatory diseases and identify associated characteris-tics. Methods: Physical function and social role satisfaction were evaluated through the Patient-reported Outcomes Measurement System. Besides comparison between groups, univariate and multivariable logistic regression analyses were performed to identify independent predictors. Results: Two hundred sixty-five patients with immune-mediated inflammatory diseases and 206 controls were recruited. Compared to controls, patients with inflammatory bowel diseases had impaired physical function (p<0.001), while patients with inflammatory arthritis reported impair-ment in both domains (p<0.001, each). In the univariate logistic regression, gender, high school educational level, physical activity, and occupation were positively associated with physical func-tion and social role satisfaction (p<0.001; p=0.001; p<0.001; p=0.001 and p<0.001; p=0.012; p=0.008; p=0.004, respectively). Active disease and steroids were inversely associated with phys-ical function and social roles satisfaction (p=0.033; p=0.022 and p=0.002; p=0.038, respectively). Further associations were found between age and physical function (p=0.002) and biological treatment and ESR with social roles satisfaction (p<0.001; p=0.043; respectively). In the multivar-iable regression, gender was found to be associated with physical function (p<0.001) and social roles satisfaction (p=0.003). Negatively associated factors were biological treatment for satisfac-tion with social roles (p<0.001) and steroids for physical function (p=0.021), and social roles sat-isfaction (p=0.018). Conclusion: Immune-mediated inflammatory diseases determine alterations in physical function and social life satisfaction. Gender and treatment are independently associated factors. Patient-reported outcomes should be considered in clinical management to define patients’ real needs.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,General Medicine

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