Affiliation:
1. Department of Pharmacy, Mohammed Al-Mana College for Medical Sciences, Abdulrazaq Bin Hammam Street, Al
Safa, Dammam 34222, Saudi Arabia
Abstract
Aim:
Various research was conducted during the last decade, with inconsistent findings regarding
iron death anaemia (IDA) perils vis-à-vis utilization of proton-pump inhibitors (PPIs). Consequently,
recent systematic review and meta-analysis were implemented to evaluate IDA-related perils
concerning the utilization of proton-pump inhibitors.
Methods:
The databases of EBSCOhost, PubMed® and Cochrane Central were searched from the research
outset until February 28, 2021 purposely to identify all research with objectives that align with
the present research investigation. The Newcastle-Ottawa Scale (NOS) was utilized for the evaluation
of the research investigation standard. The prime (1º) goal of the research was to gauge IDA peril
among users of proton-pump inhibitors (PPI). For data processing, RevMan (Review Manager) version
5.4 was employed.
Results:
In total, fourteen investigations research was employed in this systematic review and metaanalysis.
The combined relative risk of nine research exhibited a numerically consequential interrelation
betwixt the utilization of proton-pump inhibitors and IDA peril (RR 2.56 [95% CI 1.43–4.61], p <
0.00001). Contemporary systematic review and meta-analysis examination posit that proton-pump inhibitor
consumers are prone to greater peril of coming down with IDA in comparison to non-PPI users.
Conclution:
In keeping with the findings of my research, prescriber physicians should exercise caution
when prescribing PPIs to individuals taking it for a long time to avoid the peril of IDA. Additionally,
their serum iron level should be checked to ensure that proton-pump inhibitors are safe.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics
Cited by
3 articles.
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