Affiliation:
1. Vice Chancellor, Delhi Pharmaceutical Sciences and Research University, Delhi 110017,, India
Abstract
Introduction: The present investigation was carried out to study antihyperglycemic activity
of formulation prepared by spray-dried powder of fruit juice of E. officinalis (SDF) on animal
model of type 1 diabetes.
Methods: Hyperglycemia was produced by streptozotocin 45 mg/kg i.v. and formulation was administered
orally (100 mg/kg) for 28 days to diabetic rats. At the end of 28 days various biochemical parameters
such as serum glucose, insulin, AUC<sub>glucose</sub>, AUC <sub>insulin</sub> and lipid profile were estimated.
Results: STZ induced rats showed signs and symptoms of diabetes such as body weight loss,
polydipsia, polyuria, polyphagia, treatment with formulation produced slight improvement in these
symptoms. Treatment with formulation to diabetic rat produced significant decrease in serum glucose,
AUC<sub>glucose</sub>, triglyceride, cholesterol, LDL cholesterol, VLDL cholesterol. However, insulin,
AUC<sub>insulin</sub> and serum high density lipoprotein level were not significantly affected after treatment.
Treatment also produced reduction in malonaldehyde levels and increased antioxidant enzymes levels
in diabetic rats.
Conclusion: Thus, formulation of E. officinalis significantly improved glucose and lipid dysfunction
and oxidative stress in diabetic status. The mechanism of its antidiabetic activity may be either increase
in peripheral glucose uptake, reduced insulin resistance or antioxidant property of formulation.
Publisher
Bentham Science Publishers Ltd.
Subject
Public Health, Environmental and Occupational Health,Nutrition and Dietetics,Food Science
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