Traditional Medicinal Plants Usage in Cancer Therapy and Chemoprevention: A Review of Preclinical and Clinical Studies

Abstract

Abstract: Cancer has become a significant public health concern in the past few decades, and it is now the world's second cause of death. Although there are various types of cancer treatments, such as chemotherapy, immune therapy, radiation, hormone therapy, gene editing, etc., they all have adverse reactions and significant failings. Plant and dietary mixtures have been utilized to treat malignant growth over the entire course of time. These mixtures likewise might be helpful in anticipation of malignant growth. Chemoprevention is cancer prevention that makes use of plant phytochemicals and synthetic substances. Because of their reduced toxicity and inexpensive cost, phytoconstituents are gaining much interest in chemoprevention effectiveness. As a result, the chemopreventive power of naturally occurring phytochemicals is of great interest. Populace studies propose that a decreased gamble of malignant growth is related to the maximum usage of vegetables and natural products. This review summarised the latest research on plants and their chemicals targeting various malignancies and their mechanisms of cancer suppression by modulating multiple signaling pathways. It provides a small outline of green synthesized nanoparticles, an emerging area to combat cancer.