The Impact of Uremic Toxins on Alzheimer's Disease

Author:

Zhou Rong1,Ni Ruiqing23,Zheng Yuqi1,Ji Bin4,Chen Sijun1

Affiliation:

1. Department of Nephrology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China

2. Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland

3. Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland

4. Department of Radiopharmacy and Molecular Imaging, School of Pharmacy, Fudan University, Shanghai, China

Abstract

Abstract: Alzheimer's disease (AD) is the most common type of dementia, pathologically characterized by the accumulation of senile plaques and neurofibrillary tangles. Chronic kidney disease (CKD) is highly prevalent in the elderly population closely associated with the occurrence of dementia. Recent epidemiological and experimental studies suggest a potential association of CKD with AD. Both diseases share a panel of identical risk factors, such as type 2 diabetes and hypertension. However, the relationship between CKD and AD is unclear. Lower clearance of a panel of uremic toxin including cystatin- C, guanidine, and adiponectin due to CKD is implied to contribute to AD pathogenesis. In this review, we summarize the current evidence from epidemiological, experimental, and clinical studies on the potential contribution of uremic toxins to AD pathogenesis. We describe outstanding questions and propose an outlook on the link between uremic toxins and AD.

Funder

Vontobel Stiftung, University of Zurich

Publisher

Bentham Science Publishers Ltd.

Subject

Neurology (clinical),Neurology

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