The Impact of Angiotensin-Converting Enzyme Gene on Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease-Reference-Cited by-同舟云学术

The Impact of Angiotensin-Converting Enzyme Gene on Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease

Published:2020-01-28 Issue:14 Volume:16 Page:1269-1275
ISSN:1567-2050
Container-title:Current Alzheimer Research
language:en
Short-container-title:CAR

Author:

Hsieh Sun-Wung¹,Liu Ming-Wei²,Huang Ling-Chun¹,Wu Meng-Ni¹,Yang Yuan-Han¹

Affiliation:

1. Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

2. Department of Surgery, Cathay General Hospital, Taipei, Taiwan

Abstract

Background: The Angiotensin-Converting Enzyme (ACE) gene has drawn attention for its possible role in regulating the degradation of β-amyloid (Aβ), yet its role in affecting the cognitive and psychiatric symptoms of Alzheimer`s Disease (AD) patients has yet to be elucidated. Objective: This study aimed to investigate whether the ACE gene acts as a risk factor of Behavioral and Psychological Symptoms of Dementia (BPSD) in the AD population. Method: The genotyping of ACE and Apolipoprotein E gene with allele ε4(APOEε4) was determined among 360s clinically diagnosed AD patients. Symptoms and severity of BPSD were evaluated annually via Neuropsychiatric Inventory (NPI). Results: At the base measurement of the first year of patient recruitment, there were no significant contributory risk factors to NPI score. In the two-year follow-up, ACE insertion polymorphism showed a significant risk (adjusted odds ratio=1.65, 95% CI=1.1- 2.5, p=0.019) of progression of NPI total score. Conclusion: ACE gene is involved in aggravating BPSD among AD patients.

Funder

Kaohsiung Medical University Research Center

Publisher

Bentham Science Publishers Ltd.

Subject

Neurology (clinical),Neurology

Reference46 articles.

1. Finkel S.I.; Costa e Silva J.; Cohen G.; Miller S.; Sartorius N.; Behavioral and psychological signs and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment. Int Psychogeriatr (1996),8(3),497-500

2. Ferreira S.T.; Klein W.L.; The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease. Neurobiol Learn Mem (2011),96(4),529-543

3. Fein J.A.; Sokolow S.; Miller C.A.; Vinters H.V.; Yang F.; Cole G.M.; Co-localization of amyloid beta and tau pathology in Alzheimer’s disease synaptosomes. Am J Pathol (2008),172(6),1683-1692

4. Takahashi R.H.; Capetillo-Zarate E.; Lin M.T.; Milner T.A.; Gouras G.K.; Co-occurrence of Alzheimer’s disease ß-amyloid and τ pathologies at synapses. Neurobiol Aging (2010),31(7),1145-1152

5. Li K.; Wei Q.; Liu F.F.; Hu F.; Xie A.J.; Zhu L.Q.; Synaptic dysfunction in alzheimer’s disease: Aβ, tau, and epigenetic alterations. Mol Neurobiol (2018),55(4),3021-3032

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