Affiliation:
1. Biodesign Center for Environmental Health Engineering, Arizona State University, Tempe, AZ, United States
2. Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ-85287, United States
Abstract
Background:
Lifetime exposure to environmental (neuro) toxicants may contribute to the
pathogenesis of Alzheimer’s Disease (AD). Since many contaminants do not cross the blood-brain
barrier, brain tissue alone cannot serve to assess the spectrum of environmental exposures.
Methods:
We used liquid and gas chromatography tandem mass spectrometry to monitor, in postmortem
liver and adipose tissues of AD patients and age-matched controls, the occurrence and
concentrations of 11 environmental contaminants.
Results:
Seven toxicants were detected at 100% frequency: p,p'-DDE, dieldrin, triclosan,
methylparaben, bisphenol A, fipronil and tetrabromobisphenol A (TBBPA). Intra-individual, tissuedependent
differences were detected for triclosan, methylparaben, fipronil and TBBPA. High
concentrations of p,p’-DDE and dieldrin were observed in adipose tissue when compared to liver values
for both AD cases and controls.
Conclusion:
This study provides vital data on organ-specific human body burdens to select analytes and
demonstrate the feasibility of analyzing small sample quantities for toxicants suspected to constitute AD
risk factors.
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Neurology,Neurology
Cited by
13 articles.
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