Longitudinal Functional Magnetic Resonance Spectroscopy Study in Subjects with Mild Cognitive Impairment and Alzheimer’s Disease

Author:

Cho Soo-Hyun1,Rhee Hak Y.2,Oh Janghoon3,Lee Jin S.4,Park Soonchan5,Shin Won C.2,Paik Jong-Woo6,Ryu Chang-Woo5,Park Key C.4,Jahng Geon-Ho5

Affiliation:

1. Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, #42 Jebong-ro, Dong-gu, Gwangju, 61469,Korea

2. Department of Neurology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, 05278,Korea

3. Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, #26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447,Korea

4. Department of Neurology, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, #23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447,Korea

5. Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, 05278,Korea

6. Department of Psychiatry, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, #23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447,Korea

Abstract

Background: Longitudinal changes of brain metabolites during a functional stimulation are unknown in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) subjects. Objective: This study was to evaluate the longitudinal changes of brain metabolites using proton magnetic resonance spectroscopy (1H MRS) in response to treatment during a memory task in the subjects of cognitive normal (CN), aMCI, and AD. Methods: We acquired functional magnetic resonance spectroscopy (fMRS) data from 28 CN elderly, 16 aMCI and 12 AD subjects during a face-name association task. We measured fMRS metabolite ratios over 24 months in the 8-month apart, determined the temporal changes of the metabolites, and evaluated the differences among the three groups under the three different conditions (base, novel, repeat). Results: The results of comparisons for the three subject groups and the three-time points showed that tNAA/tCho and tCr/tCho were statistically significant among the three subject groups in any of the three conditions. The dynamic temporal change measurements for the metabolites for each condition showed that Glx/tCho and Glu/tCho levels at the third visit increased significantly compared with in the first visit in the novel condition in the AD group. Conclusion: We found declines in tNAA/tCho and tCr/tCho in the aMCI and AD subjects with increasing disease severity, being highest in CN and lowest in AD. The Glx/tCho level increased temporally in the AD subjects after they took an acetylcholine esterase inhibitor. Therefore, Glx may be suitable to demonstrate functional recovery after treatment.

Funder

National Research Foundation of Korea (NRF) grants funded by Ministry of Science and ICT, Republic of Korea

Convergence of Conventional Medicine and Traditional Korean Medicine R&D program funded by the Ministry of Health & Welfare through the Korea Health Industry Development Institute

Korean Health Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea

Publisher

Bentham Science Publishers Ltd.

Subject

Neurology (clinical),Neurology

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