Unfolded p53 as a Marker of Oxidative Stress in Mild Cognitive Impairment, Alzheimer’s and Parkinson’s Disease

Author:

García Sara1,Amor-Gutiérrez Olaya2,Palomares-Albarrán María2,Toyos-Rodríguez Celia2,Cuetos Fernando1,Martínez Carmen3,Costa-García Agustín2,Fernández-Sánchez Maria Teresa4,de la Escosura-Muñiz Alfredo2,Novelli Antonello1

Affiliation:

1. Department of Psychology, University of Oviedo, Oviedo, Spain

2. NanoBioAnalysis Group-Department of Physical and Analytical Chemistry, University of Oviedo, Oviedo, Spain

3. University Hospital of Cabueñes, Gijon, Spain

4. Biotechnology Institute of Asturias, University of Oviedo, Oviedo, Spain

Abstract

Aims: There are several candidate biomarkers for AD and PD which differ in sensitivity, specificity, cost-effectiveness, invasiveness, logistical and technical demands. This study is aimed to test whether plasma concentration of unfolded p53 may help to discriminate among the neurodegenerative processes occurring in Mild Cognitive Impairment, Alzheimer’s disease and Parkinson’s disease. Method: An electrochemical immunosensor was used to measure unfolded p53 in plasma samples of 20 Mild Cognitive Impairment (13 males/7 females; mean age 74.95±5.31), 20 Alzheimer’s (11 males/9 females; mean age: 77.25±7.79), 15 Parkinson’s disease patients (12 males/3 females; mean age: 68.60 ± 7.36) and its respective age/sex/studies-matched controls. Result: We observed a significantly higher concentration of unfolded p53 in the plasma of patients of each of the three pathologies with respect to their control groups (p=0.000). Furthermore, the plasma concentration of unfolded p53 was significantly higher in Alzheimer’s disease patients in comparison with Mild Cognitive Impairment patients (p=0.000) and Parkinson’s disease patients (p=0.006). No significant difference between Mild Cognitive Impairment and Parkinson’s disease patients was observed (p=0.524). Conclusion: Our results suggest that unfolded p53 concentration in the plasma may be a useful biomarker for an undergoing neuropathological process that may be common, albeit with different intensity, to different diseases.

Funder

Asturias Regional Government

Spanish Ministry of Economy and Competitiveness

Vice-Rectorate for Research of the University of Oviedo. A.

de la Escosura- Muñiz also acknowledges the Spanish Ministry of Science and Innovation MICINN (Spain), Ramón y Cajal' Research Fellow

Publisher

Bentham Science Publishers Ltd.

Subject

Neurology (clinical),Neurology

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