B Lymphocytes Are Predictors of Insulin Resistance in Women with Gestational Diabetes Mellitus-Reference-Cited by-同舟云学术

B Lymphocytes Are Predictors of Insulin Resistance in Women with Gestational Diabetes Mellitus

Published:2019-04-15 Issue:3 Volume:19 Page:358-366
ISSN:1871-5303
Container-title:Endocrine, Metabolic & Immune Disorders - Drug Targets
language:en
Short-container-title:EMIDDT

Author:

Zhuang Yan¹,Zhang Jin¹,Li Yiwei¹,Gu Hongqin¹,Zhao Jinyan¹,Sun Ya¹,Wang Rencheng¹,Zhang Chunyan¹,Chen Wen¹,Weng Jianrong¹,Qi Lan¹,Lu Huifang¹,Zhang Jiarong¹,Liu Qin²,He Yinyan¹,Xu Xianming¹

Affiliation:

1. Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China

2. The Wistar Institution, 19104, Philadelphia, United States

Abstract

Backgroud: The present study aimed to investigate the association between immune cells and gestational diabetes mellitus (GDM) and identify a reasonable predictor of insulin resistance in women with GDM. Objective: The clinical and biochemical characteristics of 124 women with GDM and 168 healthy pregnant women were compared. Methods: The percentage of immune cells in the blood of the subjects was analyzed by flow cytometry. Pearson’s correlation analysis revealed the correlation between the percentage of B lymphocytes and insulin resistance. A cutoff point was determined for the percentage of B lymphocytes, based on insulin resistance, using receiver operating characteristic (ROC) curves. Results: Compared to the healthy pregnant women, the percentages of B lymphocytes and IgA produced by B-cells were significantly different in women with GDM. The percentage of B lymphocytes was positively related to insulin resistance.The number of 14.05% of B lymphocytes was an optimal cutoff point that predicted the insulin resistance in women with GDM. Conclusion: The percentage of B lymphocytes was positively associated with insulin resistance, and hence, might serve as an appropriate predictor of insulin resistance in women with GDM.

Funder

Shanghai Talent Development Foundation of China

Shanghai Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Immunology and Allergy,Endocrinology, Diabetes and Metabolism

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