Metabolic Imbalance and Vitamin D Deficiency in Type 1 Diabetes in the Algerian Population-Reference-Cited by-同舟云学术

Metabolic Imbalance and Vitamin D Deficiency in Type 1 Diabetes in the Algerian Population

Published:2019-11-11 Issue:8 Volume:19 Page:1172-1176
ISSN:1871-5303
Container-title:Endocrine, Metabolic & Immune Disorders - Drug Targets
language:en
Short-container-title:EMIDDT

Author:

Mihoubi Esma¹,Raache Rachida¹,Amroun Habiba²,Azzouz Malha³,Galleze Assia¹,Zaabat Nesrine⁴,Aissou Abdelghani⁴,Ferhat Amina⁵,Guettaf-Sadi Hassiba⁵,Boutemeur Amel⁵,Aoudia Zoulikha⁵,Boudiba Aissa³,Touil-Boukoffa Chafia¹,Abbadi Mohamed C.⁴,Attal Nabila⁴

Affiliation:

1. Laboratory of Cellular and Molecular Biology, Cytokine and NO Synthases. University of Science and Technology, Houari Boumediene (USTHB), Algiers, Algeria

2. Central Laboratory, Parnet Hospital, Algiers, Algeria

3. Diabetology Department of Mustapha Pacha Hospital, Algiers, Algeria

4. Immunology Department, Pasteur Institute of Algiers, Algeria

5. University of Boumerdes, Faculty of Biology, Algeries, Algeria

Abstract

Background: We aimed to assess Vitamin D levels in patients with Type 1 Diabetes (T1D) and to investigate the correlation between vitamin D and metabolic imbalance. Material and Methods: For our study, we selected thirty-one patients with T1D without complications and fifty-seven healthy controls. Diabetic patients were diagnosed using the criteria of the World Health Organization/American Diabetes Association. Vitamin D, Parathyroid Hormone (PTH), insulin and C peptide assay were performed using chimilunescence. Glucose level, lipid profile, glycated haemoglobin (HbA1c) and ionogram were also analysed. Results: Vitamin D, HbA1c and Gly levels were found to be significant in T1D patients than in controls (P<0.5). However, for PTH, no significant difference was observed (P > 0. 05) and the results show a non-significant difference of total cholesterol potassium, sodium, phosphor and calcium concentration averages. Conclusion: Our results indicate that the deficiency of VD is associated with an increased risk of T1DM in Algerian population.

Publisher

Bentham Science Publishers Ltd.

Subject

Immunology and Allergy,Endocrinology, Diabetes and Metabolism

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