Affiliation:
1. Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Brazil
2. Department of Biological Sciences, Division of Cardiovascular Physiology, Federal University of Goias, Jatai, Brazil
Abstract
Aim:
We hypothesized that IL-1β concentrations are augmented in overweight adolescents,
who do not display metabolic syndrome. Additionally, we aimed to correlate the IL-1β concentrations
with several established risk factors for CVD.
Methods:
Overweight or control subjects, aging from 14-18 years, were classified according to their
adjusted body mass index and evaluated for biochemical and anthropometric parameters. The proinflammatory
cytokine IL-1β was assessed in the serum.
Results:
Increased body fat percentage, waist circumference, triglycerides, total cholesterol, Very
Low-Density Lipoprotein (VLDL) cholesterol, Low-Density Lipoprotein (LDL) cholesterol, Castelli I
index, IL-1β, and IL-8 levels, were observed in overweight adolescents. No differences were observed
in systolic blood pressure, diastolic blood pressure, glucose or High-Density Lipoprotein (HDL) cholesterol.
Positive correlations between IL-1β with anthropometric and or biochemical parameters were
found.
Conclusion:
In conclusion, increased IL-1β levels correlate to dyslipidemic factors and may further
support low-grade inflammation. IL-1β may further predict the early onset of cardiovascular disease in
this population, taking into consideration its important regulatory role.
Funder
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Fundação de Amparo à Pesquisa do Estado de Mato Grosso
Publisher
Bentham Science Publishers Ltd.
Subject
Immunology and Allergy,Endocrinology, Diabetes and Metabolism
Cited by
10 articles.
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