Affiliation:
1. College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, P.R. China
2. Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, China Jiliang University,
Hangzhou, China
3. Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, China Jiliang University, Hangzhou, China
Abstract
Background:
Quercetin is a kind of flavonoid with important bioactivities, such as
hypoglycemic, antioxidant, anti-inflammatory, and anti-allergic properties. Although it is
unstable, it is worth exploring how to better exert its anti-allergic effect.
Objective:
The current study aimed to elucidate the anti-allergic effect of quercetin liposomes on
RBL-2H3 cells in vitro.
Methods:
Quercetin liposomes were prepared to improve the anti-allergic activity of quercetin
through a green thin-film dispersion method. We compared the anti-allergic effects of quercetin
and quercetin liposomes in RBL-2H3 cells. The anti-allergic activity of the quercetin liposomes
was evaluated by the level of β-hexosaminidase, histamine, Ca2+, IL-4, IL-8, and MCP-1.
Results:
The results showed that quercetin liposomes could significantly restrain the release of
β-hexosaminidase and histamine, calcium influx, and the expression of inflammatory factors,
whose effect is stronger than quercetin.
Conclusion:
Collectively, our research suggests that the quercetin liposome can be used as a
potential allergy antagonist.
Publisher
Bentham Science Publishers Ltd.
Subject
Immunology and Allergy,Endocrinology, Diabetes and Metabolism
Cited by
7 articles.
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