Creatinine Clearance Measurement with Bioelectrical Impedance Analysis in Heart Failure Patients: Comparison with Estimated-Creatinine Clearance Formulas

Author:

Scicchitano Pietro1ORCID,Iacoviello Massimo2,Guida Piero3,De Palo Micaela4,Potenza Angela1,Basile Marco1,Sasanelli Paolo1,Trotta Francesco1,Sanasi Mariella1,Caldarola Pasquale5,Massari Francesco1

Affiliation:

1. Cardiology Section, F. Perinei Hospital, Altamura, Bari, Italy

2. Cardiology Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

3. Ospedale Generale Regionale "F. Miulli", Acquaviva delle Fonti, Bari, Italy

4. Cardiac Surgery Section, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy

5. Cardiology Section, S. Paolo Hospital, Bari, Italy

Abstract

Background: Kidney disease is common in patients with heart failure (HF). The Donadio equation combines plasma creatinine and bioimpedance vector analysis (BIVA) to estimate creatinine clearance. This study aimed to compare the Donadio formula to the Cockcroft-Gault (CG), Modification of Diet in Renal Disease Study (MDRD-4), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in patients with HF. Methods: We analysed data from 900 patients (mean age: 76 ± 10 years) with HF. All of them underwent clinical, laboratory, BIVA, and echocardiographic evaluations. Results: Donadio equation overestimated eGFR as compared to CG and CKD-EPI formulas (+6.8 and +12 mL/min/1.73 m2, respectively) while computing similar results to MDRD-4 (overestimation: +0.1 mL/min/1.73 m2). : According to the different formulas, the prevalence of renal insufficiency (eGFR< 30 ml/min/1.73 m2) in relation to the different formulas was as follows: 24% with Donadio, 21% with CG, 13% with MDRD-4, and 23% with CKD-EPI formulas. All the equations demonstrated a high precision rate (r>0.8 for all). Conclusions: The Donadio formula provided an estimation of GFR comparable to MDRD-4 in HF patients, independently from acute or chronic HF conditions. The use of BIVA in HF patients may be adopted both for HF management and for evaluating kidney function.

Publisher

Bentham Science Publishers Ltd.

Subject

Immunology and Allergy,Endocrinology, Diabetes and Metabolism

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