Novel 2,4- diaminopyrimidine 5-carboxamides as c-Jun N-terminal Kinase Inhibitors for Treating the Liver Fibrotic Disorder
Author:
Affiliation:
1. Conju-probe, San Diego, California, USA
2. Department of Chemistry, Bharath University, Chennai, Tamil Nadu, 600126, India
Abstract
Publisher
Bentham Science Publishers Ltd.
Subject
Immunology and Allergy,Endocrinology, Diabetes and Metabolism
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3. Kluwe J.; Pradere J.P.; Gwak G.Y.; Mencin A.; De Minicis S.; Österreicher C.H.; Colmenero J.; Bataller R.; Schwabe R.F.; Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. Gastroenterology 2010,138(1),347-359
4. Vallerie S.N.; Hotamisligil G.S.; The role of JNK proteins in metabolism. Sci Transl Med 2010,2(60),60rv5
5. Kodama Y.; Kisseleva T.; Iwaisako K.; Miura K.; Taura K.; De Minicis S.; Österreicher C.H.; Schnabl B.; Seki E.; Brenner D.A.; c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology 2009,137(4),1467-1477.e5
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