Affiliation:
1. Department of Clinical Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072,
China
2. Department of Clinical Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China
Abstract
Background:
Diabetes mellitus (DM) is a metabolic disorder characterized by progressive
β cell dysfunction. Sheng-Mai Injection (SMI), a Traditional Chinese medicine preparation,
is widely used for DM and its related complications.
Objective:
This meta-analysis aimed to summarize the applications of SMI in DM and related
complications.
Methods:
Eight databases were searched, and meta-analyses were performed.
Results:
Fifteen studies, including 1273 participants, were included. All studies and participants
included were from China. Pooled effects showed that SMI might reduce glycated hemoglobin
(MD -0.46%; 95% CI -0.89 to -0.03; P < 0.01), fasting blood glucose (MD -0.83 mmol/L; 95%
CI -1.30 to -0.36; P < 0.01), two-hour postprandial glucose (MD -1.27 mmol/L; 95% CI -1.96 to
-0.58; P < 0.01), 24-hour urinary protein (MD -0.28 mg; 95% CI -0.51 to -0.06; P = 0.01), blood
urea nitrogen (MD -1.31 mg; 95% CI -2.08 to -0.54; P < 0.05), Scr (MD -2.60; 95% CI -3.43 to
-1.77; P < 0.05), ulnar nerve motor nerve conduction velocity (MNCV) (MD 1.45; 95% CI 0.03
to 2.87; P < 0.05), and tibial nerve sensory nerve conduction velocity (SNCV) (MD 1.84; 95%
CI 0.1 to 3.58; P < 0.05). There was no evidence of an effect on common peroneal nervous
MNCV and SNCV, tibial nerve MNCV, median nerve MNCV, and SNCV. Adverse effects included
less frequent gastrointestinal reactions, elevated transaminase, leucopenia, fever, and rash.
Conclusion:
Combination use of SMI based on conventional hypoglycemic treatment can significantly
improve HbA1c, FBG, and 2hPG in DM and reduce 24-hour urinary protein, Scr, and
BUN in DM patients. SMI was found to have no effect on the neurological function of diabetic
peripheral neuropathy.
Funder
Science and Technology Program of Sichuan Province
Publisher
Bentham Science Publishers Ltd.
Subject
Immunology and Allergy,Endocrinology, Diabetes and Metabolism