The Putative Adverse Effects of Bisphenol A on Autoimmune Diseases

Abstract

: Bisphenol A (BPA) is a monomer that is widely used in the manufacture of polycarbonate plastics including storage plastics and baby bottles, and is considered one of the most widely used synthetic compounds in the manufacturing industry. Exposure to BPA mainly occurs after oral ingestion and results from leaks into food and water from plastic containers and according to epidemiological data exposure is widespread and estimated to occur in 90% of individuals. BPA exertspleiotropiceffects and demonstrates estrogen like effects, thus considered an endocrine disrupting chemical. Growing body of evidence highlight the role of BPA in modulating immune responses and signaling pathways resulting in a proinflammatory response by enhancing the differential polarization of immune cells and cytokine production profile to one that is consistent with proinflammation. Indeed, epidemiological studies have uncovered associations between several autoimmune diseases and BPA exposure. Data from animal models provided consistent evidence highlighting the role of BPA in the pathogenesis, exacerbation and perpetuation of various autoimmune phenomena including neuroinflammation in the context of multiple sclerosis, colitis in inflammatory bowel disease, nephritis in systemic lupus erythematosus, and insulitis in type 1 diabetes mellitus. Given the wide spread of BPA use and its effects in immune systemdysregulation, a call for careful assessment of patients’ risks and for public health measures are needed to limit exposure and subsequent deleterious effects. The purpose of this paper is to explore the autoimmune triggering mechanisms and present the current literature supporting the role of BPA in the pathogenesis of autoimmune diseases.