Affiliation:
1. Department of Biochemistry, AIIMS, Bhubaneswar, Odisha-751019, India
Abstract
Background:
Serum ferritin concentrations are altered in hypothyroidism, but there is
no available literature regarding the status of serum ferritin in anti-thyroid peroxidase (anti-TPO)
positive hypothyroidism. The objectives of our study were to evaluate the titer of anti-TPO and
serum ferritin in newly diagnosed hypothyroid patients and to find out any difference in serum ferritin
concentration between antibody-positive and antibody-negative patients.
Methods:
A total of 143 subjects above the age of 18 years were recruited, and serum Thyroid Stimulating
Hormone (TSH), free T3, free T4, anti-TPO, and ferritin were assayed by chemiluminescence
method. According to their serum analysis findings, three groups were made as Group 1 of
49 subjects with hypothyroidism and anti-TPO positive, Group 2 of 47 subjects with hypothyroidism
and anti-TPO negative, and Group 3 of 47 euthyroid and anti-TPO negative controls.
Results:
Kruskal Wallis H test was applied, and the difference in concentration of TSH, FT3, FT4,
Ferritin, anti-TPO amongst the three groups was found to be significant. The relationship between
anti-TPO levels and serum ferritin concentration was further studied by multinomial logistic regression.
We have found that there is a significant difference between the concentrations of ferritin;
hence, it is highly likely that those with a high level of anti-TPO antibody shall have a higher concentration
of serum ferritin.
Conclusion:
Ferritin concentrations were decreased in anti-TPO negative hypothyroidism, but in
the case of anti-TPO positive hypothyroidism the ferritin concentrations are raised. Hence, hypothyroidism
should not always be considered as an iron deficiency state.
Publisher
Bentham Science Publishers Ltd.
Subject
Immunology and Allergy,Endocrinology, Diabetes and Metabolism
Cited by
3 articles.
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