Analysis of Interleukin-1 Receptor Antagonist Variable Number Tandem Repeat Variant in Recurrent Aphthous Stomatitis

Author:

Tekcan Akin1ORCID,Yigit Serbulent2ORCID,Nursal Ayse F.3ORCID,Tumer Mehmet K.4ORCID,Yerliyurt Kaan5ORCID,Kuruca Nilufer6ORCID

Affiliation:

1. Department of Medical Biology, Faculty of Medicine, Amasya University, Amasya,Turkey

2. Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biology, Tokat,Turkey

3. Hitit University, Faculty of Medicine, Department of Medical Genetics, Corum,Turkey

4. Gaziosmanpasa University, Faculty of Dentistry, Department of Maxillofacial Surgery, Tokat,Turkey

5. Gaziosmanpasa University, Faculty of Dentistry, Department of Prosthodontics, Tokat,Turkey

6. Ondokuz Mayıs University, Faculty of Veterinary Medicine, Department of Pathology, Samsun,Turkey

Abstract

Background/Aims: Recurrent aphthous stomatitis (RAS) is one of the common oral inflammatory diseases. As immunological and genetic factors have been held responsible for the pathogenesis of RAS, the objective of this study was to determine whether the interleukin-1 receptor antagonist (IL-1Ra) gene variable number tandem repeat (VNTR) variant is a risk factor for the development of RAS in Turkish patients and to define its contribution to the increased risk. Methods: The IL-1Ra VNTR variant was evaluated in 169 RAS patients and 171 healthy controls by the polymerase chain reaction (PCR) method. Results: No statistically significant difference was found in the genotype distributions and allele frequencies of IL-1Ra VNTR variant between RAS patients and healthy controls. Conclusion: Lack of association between IL-1Ra VNTR variant and RAS could indicate that IL-1Ra has no significant role in the pathophysiology of RAS. However, it still appears to be very worthwhile to continue to search for cytokine gene variants in order to predict the development of such disease.

Publisher

Bentham Science Publishers Ltd.

Subject

Immunology and Allergy,Endocrinology, Diabetes and Metabolism

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The Association of Interleukin 1 Beta in Recurrent Aphthous Stomatitis – A Systematic Review;Journal of Pharmaceutical Research International;2021-10-18

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