False Positive of 68Ga-DOTATATE PET-CT in a Paraganglioma

Author:

Zampetti Benedetta1ORCID,Attanasio Roberto2ORCID,Boniardi Marco3,Cozzi Renato1ORCID

Affiliation:

1. ASST Grande Ospedale Metropolitano Niguarda, Endocrinology Department, Milan, Italy

2. IRCCS Orthopedic Institute Galeazzi, Endocrinology Service, Milan, Italy

3. ASST Grande Ospedale Metropolitano Niguarda, General Oncologic and Mini-invasive Surgery Department, Milan, Italy

Abstract

Background: Functional imaging with 68Ga-DOTATATE PET-CT is widely employed to detect both primary and metastatic pheochromocytomas and paragangliomas (PGL), but its results may be occasionally misleading as in the case here reported. Case Presentation: We report here a 75-year-old woman with an interaortocaval PGL that was diagnosed after a hypertensive crisis occurring during the resection of a kidney tumor. 68Ga-DOTATATE PET-CT disclosed pathologic uptake in the abdomen and at the iliac crest. After the resection of the abdominal tumor, with the histological confirmation of PGL, arterial blood pressure and metanephrine levels were normalized. Genetic testing was negative. Thereafter, the bone lesion increased in size and became painful, requiring multiple medications. A selective biopsy disclosed a metastatic lesion arising from the renal tumor. Conclusion: The false-positive result of 68Ga-DOTATATE PET-CT is discussed.

Publisher

Bentham Science Publishers Ltd.

Subject

Immunology and Allergy,Endocrinology, Diabetes and Metabolism

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