Affiliation:
1. Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
2. Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
Abstract
Background:
Nickel (Ni) is mostly applied in a number of industrial areas such as printing
inks, welding, alloys, electronics and electrical professions. Occupational or environmental exposure to
nickel may lead to cancer, allergy reaction, nephrotoxicity, hepatotoxicity, neurotoxicity, as well as
cell damage, apoptosis and oxidative stress.
Methods:
In here, we focused on published studies about cell death, carcinogenicity, allergy reactions
and neurotoxicity, and promising agents for the prevention and treatment of the toxicity by Ni.
Results:
Our review showed that in the last few years, more researches have focused on reactive oxygen
species formation, oxidative stress, DNA damages, apoptosis, interaction with involving receptors
in allergy and mitochondrial damages in neuron induced by Ni.
Conclusion:
The collected data in this paper provide useful information about the main toxicities induced
by Ni, also, their fundamental mechanisms, and how to discover new ameliorative agents for
prevention and treatment by reviewing agents with protective and therapeutic consequences on Ni
induced toxicity.
Publisher
Bentham Science Publishers Ltd.
Subject
Immunology and Allergy,Endocrinology, Diabetes and Metabolism
Reference173 articles.
1. Rana S.V.; Metals and apoptosis: Recent developments. J Trace Elem Med Biol 2008,22(4),262-84-84
2. Das K.K.; Das S.N.; Dhundasi S.A.; Nickel, its adverse health effects
3. Sunderman F.W.; Biological monitoring of nickel in humans. Scand J Work Environ Health 1993,19(Suppl. 1),34-38
4. Miller A.B.; Review of extant community-based epidemiologic studies on health effects of hazardous wastes. Toxicol Ind Health 1996,12(2),225-233
5. Nielsen F.H.; Shuler T.R.; McLeod T.G.; Zimmerman T.J.; Nickel influences iron metabolism through physiologic, pharmacologic and toxicologic mechanisms in the rat. J Nutr 1984,114(7),1280-1288
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献