Affiliation:
1. Universidad Autónoma de San Luis Potosí
Abstract
In Mexico, according to data from the ENSANUT, 2012, 6.4 million of Mexicans were diagnosed with diabetes mellitus (DM). Currently, there are several reports in the scientific literature supporting the use of plants for the treatment of T2DM. Justicia spicigera (JS) is widely distributed in Huasteca Potosina and its ethanolic extract (EEJS) has recently been shown that it has a hypoglycemic effect in normoglycemic rats and streptozotocin-induced DM model; however only its acute toxicity has been evaluated. therefore, it is necessary to evaluate the toxicity for prolonged periods. Oral toxicity was evaluated by repeated dose administration model for 30 days. The results showed that administration of EEJS induced mild adverse effects, particularly related to behavioral abnormalities. Additional experiments are currently being carried out in our laboratory to evaluate its chronic toxocity.
Subject
General Earth and Planetary Sciences,General Environmental Science
Reference18 articles.
1. Alanís-Garza BA, González-González GM, Salazar-Aranda R, Waksman de Torres N, Rivas-Galindo VM. (2007). Screening of antifungal activity of plants from the northeast of Mexico. J Ethnopharmacol, 114(3):468-71.
2. Alonso-Castro AJ, Villarreal ML, Salazar-Olivo LA, Gomez-Sanchez M, Dominguez F, Garcia-Carranca A. (2011). Mexican medicinal plants used for cancer treatment: pharmacological, phytochemical and ethnobotanical studies. J Ethnopharmacol, 133(3):945-72.
3. Alonso-Castro JA, Maldonado-Miranda JJ, Zarate-Martinez A, Jacobo-Salcedo M del R, Fernández-Galicia C, Alejandro Figueroa-Zuñiga L, Abel Rios-Reyes N, Angel de León-Rubio M, Andrés Medellín-Castillo N, Reyes-Munguia A, Méndez-Martínez R, Carranza-Alvarez C. (2012). Medicinal plants used in the Huasteca Potosina, Mexico. J Ethnopharmacol, 143(1):292-8.
4. Andrade-Cetto A, Heinrich M. (2005). Mexican plants with hypoglycaemic effect used in the treatment of diabetes. J Ethnopharmacol, 93, 248–325.
5. Arellano-Rodriguez JA, Flores Guido JS, Tun J, Garridoy MM, Cruz Bojorquez. (2003). Nomenclature, lifestyle, use, management and distribution of the plant species of the Yucatan Peninsula. Yucatan Ethnoflora, 20.5–6.