THE SUB-ACUTE TOXICITY OF THE DISINFECTIOUS PREPARATION "IODOPOVIDONE"

Abstract

The results of a preclinical study of the subacute toxicity of the disinfectant "Iodopovidone" are presented. The purpose of the experiment reflected in the article was to continue a series of preclinical studies of the disinfectant Iodopovidone on laboratory animals by examining subacute toxicity, to confirm good animal tolerance and the drug belongs to the 4th toxicity class – low-toxic substances. The experiment was carried out on laboratory white rats, which were kept in the vivarium of the Faculty of Veterinary Medicine of the National University of Life and Environmental Sciences of Ukraine in compliance with the requirements of the European Convention for the Protection of Vertebrate Animals used for scientific experiments or for other scientific purposes and the Law of Ukraine "On the Protection of Animals". The subacute toxicity of the disinfectant "Iodopovidone" was studied using dermal application. The effect of the drug was evaluated by analyzing the change in biochemical parameters of blood serum and hematological parameters of the blood of laboratory animals in dynamics after 6, 24 and 48 hours. The results of determining the parameters of subacute toxicity when applied to the skin indicate the absence of an irritating effect of the drug on the skin. Under the influence of the drug on the organism of animals for six hours, a slight fluctuation in hematological and biochemical blood parameters was revealed, which approached those of the control group of animals within 48 hours, except for the level of glucose, but this did not affect the general condition of the animals. The use of the drug at a dose of 2900 mg/kg of body weight does not cause the death of animals, which confirms the low toxicity of the drug and belonging to the 4th class of toxicity according to the current sanitary and hygienic standards, which is promising for use in poultry farming and requires further studies of chronic toxicity and toxicity in inhalation use.