Relationship between fibroblast growth factor 23 level and vitamin D status in chronic kidney disease: A cross-sectional study

Author:

Ratu Andi PuspaORCID,Rasyid HaeraniORCID,Bakri SyakibORCID,Mansyur Andi Makbul AmanORCID,Iskandar HarunORCID,Seweng ArifinORCID

Abstract

Complications stemming from chronic kidney disease (CKD) significantly contribute to increased morbidity and mortality rates. During the early stages of CKD, a delicate balance in homeostasis and mineral regulation is maintained largely due to fibroblast growth factor 23 (FGF-23). However, as kidney function declines, there is a detrimental effect on vitamin D synthesis. Understanding the dynamics of FGF-23 levels in relation to vitamin D status is crucial for assessing kidney function and its implications on hormonal regulation, calcium homeostasis, and cardiovascular health. Therefore, this study aimed to scrutinize and comprehend the correlation between FGF-23 levels and vitamin D status in patients afflicted with CKD. Methods. A cross-sectional study was undertaken at Dr. Wahidin Sudirohusodo Hospital in Makassar, South Sulawesi, Indonesia, involving 58 patients diagnosed with stage 3-5 non-dialysis CKD. Relationships between FGF-23 level with vitamin D level status and CKD stage were analyzed by chi-square and Kruskal-Wallis test. Results. The FGF-23 levels, with a median of 100 pg/mL as the designated cut-off, exhibit significance concerning the levels of vitamin D (p=0.003). The average values of FGF-23 in cases of deficiency and insufficiency are markedly elevated when compared to patients with sufficient vitamin D levels (p=0.016). The significance of FGF-23 levels becomes more prominent with advancing CKD stages (p=0.06). Conclusions. FGF-23 is a related marker with vitamin D deficiency in patients with CKD but is inconsistent in stage development and not an independent factor.

Publisher

Institute of Nephrology of the National Academy of Medical Sciences

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3