DYNAMICS OF THE HISTOLOGICAL STRUCTURE OF UVEAL MELANOMA IN THE KHARKIV REGION

Abstract

Resume. Uveal melanoma is one of the most common primary intraocular malignancy in adult patients (Mouriaux F., 2014). The objective of the investigation was to study the dynamics of cell type of uveal melanoma in Kharkiv region in the last 30 years. Materials and Methods. The results of histological investigations of uveal melanoma were analyzed in 82 patients (33 male and 49 female) aged from 28 to 86 years having been treated in ophthalmology department of Kharkiv regional clinical hospital during the last 30 years. The cell type tumor was determined according to the modified Callender’s classification. Results. The average age of the patients was 61,2 years. The spindle cell melanoma was diagnosed in 29 patients (35,4 %), epithelioid cell type was found in 24 (29,3 %) and mixed cell type – in 27 (32,9 %). Tumor necrosis was found in two patients. The percentage of patients with epithelioid cell melanoma during the first and second decades was about the same (61,9 % and 59,5 % respectively), and in the last 10 years some increase was noticed up to 68,4 %. Conclusions. An increase of epithelioid cells melanoma incidence from 59,6 % to 65 % was observed in Kharkiv region during the last 15 years, and up to 68,4 % - during the last 10 years.The average age of patients with uveal melanoma in Kharkiv region has increased from 57,8 to 65,6 years throughout the span of the last 15 years.