FEATURES OF THE USE OF COMPOSITE MATERIALS FOR THE TREATMENT OF PURULENT WOUNDS OF THE LOWER EXTREMITIES WITHOUT THE USE OF ANTIBIOTICS

Abstract

Summary. Introduction. The reasons for the long-term healing of TU of the lower extremities are bacterial contamination of ulcers with the formation of biofilms and growing antibiotic resistance. The urgency of the problem. The number of purulent wounds, microbial resistance and a significant frequency of recurrences of TU of the lower extremities (20–70 %) determine and substantiate the relevance of the problem. Goal. Increasing the effectiveness of treatment of patients with TU of the lower extremities against the background of CVI, without the use of antibiotics, Materials and methods. Patients with TU were divided into two groups. The first (main) group (n=57) included patients who were treated with an apatite polymer drainage bandage, the second group (comparison) included patients who were treated with traditional methods (n=53). Smears from the wound surface of TU were studied. Results and their discussion. The intensity of microbial contamination of TU before the start of treatment was 107 CFU/ml, on the 3rd day after APDB application — 104 CFU/ml, on the 5th day — 103 CFU/ml. The average rate of wound healing was 0,42 cm2/day of wound surface area. Conclusions. Application of APDB without the use of antibiotics leads to a decrease in microbial contamination. The average duration of treatment in the main group was 19,6 days, in the comparison group — 28,2 days. The speed of wound healing in patients of the main group is 2,1 times higher. In the biopsies of patients of the main group on the 14th day of treatment, a significantly greater order of collagen fibers and a greater number of fibroblasts were found.