ANTIBIOTIC RESISTANCE OF MICROFLORA IN PERFORATING CHOLECYSTITIS AND LIVER ABSCESS

Abstract

Summary. Introduction. Acute cholecystitis is the second most common cause of complicated intra-abdominal infection. Aim. Analysis of the microflora in abscess due to perforation of the gallbladder and liver abscess, determination of its resistance to antibacterial drugs. Materials and methods. The microflora of 35 patients with perforated cholecystitis and liver abscess was studied. Material for microbiological research was taken during surgery. Sampling the abscess content , tissue samples of abscess walls, blood test for sterility. Results and discussion. Content of the subhepatic abscess of patients with perforated cholecystitis were examined, 23 strains of microorganisms were detected. Gram-positive coccal microflora was represented by the genera Streptococcus, Staphylococcus, Enterococcus and Micrococcus. Rod-shaped microorganisms in the vast majority of cases were represented by the family of facultative anaerobes Enterobacteriaceae (Escherichia coli, Klebsiella oxytoca). During studying the microflora of a liver abscess, 7 strains of bacteria and 1 strain of Candida fungi were found. Conclusions. The causative agents of acute biliary infection are polymicrobial flora. Enterococcus faecalis and Escherichia coli was dominated, in abscess due to perforation of the gallbladder. Enterococcus faecium and Escherichia coli was dominated, in liver absceses . The study of the sensitivity of selected strains of microorganisms to antimicrobial drugs revealed multiple resistance. Most of the microorganisms were sensitive to cefepime, moxifloxacin, gatifloxacin, imipenem, meropenem and teicoplanin.