Platelet rich plasma therapy- Myth vs Reality

Abstract

The transformative journey of Platelet-rich plasma, fueled by discovery of Platelet-Derived Growth Factor (PDGF), underscores its regenerative potential. This comprehensive exploration delves into fundamental characteristics and applications with a focus on its growing prominence in dermatology and aesthetics. An open labelled interventional study was conducted at a tertiary health care centre in Western India to assess the efficacy and safety of PRP in various indications that mainly included patterned hair loss, post traumatic scars, acne scars, melasma and striae distensae. Patients were included in the study based on pre-determined inclusion and exclusion criteria. 6 sessions of PRP were conducted and response to therapy was evaluated using standard objective and subjective scores. The study included 60% female cases with most patients in the age group of 31-40 years (51.2%). For patterned hair loss, the mean change in hair count at end of therapy was significantly greater for baseline to final (P < 0.005). For post-traumatic scars, the mean change in Vancouver scar score at end of 6th sitting was significantly greater for first visit to last visit (P < 0.001). For melasma, the mean change in Modified MASI score at end of treatment was significantly greater for first visit to last visit (P < 0.001). For acne scars and striae distensae, the mean change in objective assessment scores was significantly greater when compared to baseline (p<0.001). Side effects were predominantly early, with 13.8% reporting pain and 10% a burning sensation, while late side effects were minimal at 3.8%. Subjective improvement was reported by 76.25% of cases, ranging from 51% to 75%. The study's results, while acknowledging certain limitations, emphasize PRP's potential efficacy in diverse dermatological conditions. The study underscores the correlation between dermatological conditions and treatment outcomes, highlighting the positive impact of PRP therapy.