Prevalence of mupirocin resistance in methicillin resistant staphylococcus aureus (MRSA) at tertiary care teaching hospital, Tamil Nadu

Abstract

Methicillin-resistant (MRSA) is major colonization in hospitalized patients and professionals. Emergence of resistance may occur due to inappropriate or over usage of antibiotics and it leads to increase morbidity and mortality among patients. Mupirocin resistance became endemic in hospitalized patients. The main objective of this study is to record the incidence of Mupirocin antibiotic resistance among MRSA isolates from hospitalized patients in a tertiary care hospital, Tamil Nadu.A prospective observational laboratory-based study was conducted in tertiary care hospital. MRSA was isolated from clinical specimens based on the preliminary test and Kirby Bauer’s Disc Diffusion Method. In MRSA isolates the Mupirocin resistance was categorized into high (200µg) and low level (5µg) discs (HiMedia) concentration.Out of 69 isolates of 32 (46%) were MRSA and 37 (54%) MSSA. Among 32 MRSA isolates, four (12%) were high-level resistance and three (10%) were low level resistance to Mupirocin. Remaining 25 (78%) MRSA isolates showed sensitive to Mupirocin agent.The study concludes, that the prevalence of Mupirocin resistance is low and is mandatory to include in the screening panel of MRSA. Regular monitoring of MRSA isolates for Mupirocin resistance is highly helpful for the eradication and complication among health care sectors.