Daptomycin susceptibility in enterococci isolated from urinary samples in a tertiary care hospital

Abstract

are gram positive cocci encountered in various human infections.The most striking feature of is their relative and absolute resistance to variety of antibiotics.Vancomycin resistant (VRE) were first described in late 1980 and the incidence of nosocomial infections by VRE being 11.9% in Asia Pacific and 35.5% in U.S. Daptomycin is a lipopeptide antibiotic with bactericidal activity . To study the daptomycin susceptibility in isolated in urinary samples. A total of 76 strains of were isolated during the study period.25 (33%) were identified as and 51 (67%) as Most of the Enterococcal isolates (82.8%) were resistant to Norfloxacin followed by 71% being resistant to tetracycline and 76% of isolates were sensitive to nitrofurantoin. Most of the isolates were multidrug resistant. Of the 76 isolated only 2(2.63%) were VRE and both the VRE strains isolated were . There was no resistance to linezolid including the VRE strains. All the isolates 76 (100%) were sensitive to daptomycin including the VRE strains. Our study mainly focused on susceptibility of enterococcal isolates in urinary samples to daptomycin which has bactericidal activity against gram positive organisms including multidrug resistant strains. This study shows growing concern for increasing antibiotic resistance in enterococcal isolates and treatment of these infections with daptomycin is invited as there are only few reports of daptomycin non susceptible (DNSE).