Spectrum of histopathological varients in urinary bladder carcinoma- Experience in a tertiary care hoapital

Abstract

Urinary bladder neoplasm are associated with significant mortality and morbidity throughout the world. It is 9 most common cancer worldwide. The clinical significance of bladder tumor depends on their histological grade, differentiation and depth of invasion of the lesions. To study histopathological spectrum of urinary bladder neoplasm and to asses this lesion with regard of age, sex and correlation of muscle invasion with tumor grade. Total 58 biopsy (53 TURBT and 5 Radical cystectomy specimen) were studied retrospectively over a period of August 2020 to July 2022 in the department of pathology, GMCH, Udaipur. These lesions were classified according to WHO classification 2016. The male to female ratio was 7.2:1 and age ranged from 41 to 85 years. Most common presenting symptoms was hematuria (91.37%). Most common lesion were infiltering urothelial carcinoma (36 cases) comprising of 33(91.66%) cases of high grade and 3 (8.33%) cases of low grade malignancy. Out of 33 High grade-infiltering urothelial carcinoma cases 25(75.75%) cases show muscle invasion. 19 cases were noninvasive urothelial lesions, 1 case was squamous cell carcinoma. Urothelial carcinoma (TCC) is the most common primary bladder carcinoma. Male are affected more common than Female. Peak incidence is seen in sixth decade of life. High grade tumor is common associated with muscle invasion.