Efficacy of intra-articular platelet -rich plasma in osteoarthritis knee

Abstract

: Knee osteoarthritis is prevalent globally among the aged adults with an ageing and increasingly obese population. It is also the second leading cause of disability and a heavy economic and social burden. The aim of this study is to analyse the efficacy of intra articular PRP injections in knee osteoarthritis. : This study is a prospective randomised controlled trial with duration of 6 months upon a sample size of 50 people with a diagnosis of Knee Osteoarthritis in which 2 injections of PRP were given 4 weeks apart and its result was analysed at 3 months and compared with initial pre-administration levels.: In a study with 50 participants (50% males, mean age 59.02 years), intra-articular PRP injections showed significant improvement in WOMAC scores for pain (75.5% to 41.1%), stiffness (84.5% to 57.5%), and physical function (46.2% to 78.2%) at 3 months. No side effects were reported. Visual Analog scale indicated a notable decrease in pain (7.44 to 4.8).: In conclusion, the administration of PRP injections showed substantial decrease in pain and other associated symptoms and an increase in physical function.