Improvement in renal function of Hyperhomocysteinemic rats by panax ginseng

Abstract

Hyperhomocysteinemia is a condition characterized by elevated levels of homocysteine in the blood, which has been linked to various cardiovascular and renal complications, including impaired renal function. , a widely used medicinal herb, has been shown to possess antioxidant, anti-inflammatory, and vasoprotective properties. However, its potential role in improving renal function in hyperhomocysteinemic conditions remains largely unexplored. Hyperhomocysteinemia is a metabolic disorder characterized by elevated levels of homocysteine in the blood, which is associated with impaired renal function. This study aimed to investigate the potential therapeutic effects of Panax Ginseng on renal function in hyperhomocysteinemic rats. Male Wistar rats There were five animals per group. Group 1 functioned as the control group, receiving a typical meal (chow feed) and unlimited water. L-methionine (1.7 g/kg/day, p.o.) was given to group 2 Hyperhomocysteinemia (HHCY Control) once daily. A modest dosage of Panax ginseng (50 mg/kg body weight) and L-methionine (1.7 g/kg/day, p.o.) was administered orally to the third group (test drug 1). The fourth group (test drug 2) got the same combination of L-methionine (1.7 g/kg/day, p.o.) and Panax ginseng (high dosage, 100 mg/kg body weight). In addition, the second, third, and fourth groups of rats received intraperitoneal doxorubicin injections at a dosage of 5 mg/kg after 1 hour of L-methionine administration at intervals of 15 days in order to produce Hyperhomocysteinemia-mediated nephrotoxicity. After 28 days of the trial, the animals were slaughtered, and the blood levels of homocysteine, creatinine, and urea were measured. We measured the amounts of urea, creatinine, and homocysteine in the serum. administration effectively improved renal function and attenuated histopathological changes in hyperhomocysteinemic rats. These findings suggest that Panax Ginseng may have a renoprotective effect in Hyperhomocysteinemia-induced renal dysfunction.