Oxidative stress and neurodegenerative diseases: Exploring natural antioxidants for therapeutic potential

Abstract

Neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's, are a growing global health challenge with no definitive cure. Oxidative stress is implicated in these disorders, and antioxidants have emerged as a promising avenue for addressing them. Research has shown the potential of natural antioxidants to combat oxidative stress in neurodegenerative disorders, but clinical trials have often failed to treat patients effectively. However, natural extracts have shown diverse molecular activities beyond their antioxidant capabilities, indicating their potential for prevention and disease management. This review will explore in vitro and in vivo research studies to highlight the promising prospects of natural antioxidants and their therapeutic applications in Neurodegenerative conditions.