A comparative review on In-vivo and In-vitro screening models for diuretic agents

Abstract

Diuretics are medications that aid in the elimination of excess urine. Water, electrolytes, and metabolic waste are all found in urine. The anatomy and physiology of the renal excretion system are the topics of the current study. Along with the reasonable diuretic activity it also highlights the kidney's involvement in renal excretion. The mechanism of several diuretic classes is connected to their active target site in this overview. Diuretics have previously demonstrated their clinical efficacy in treating conditions including hypertension, renal failure, nephritic syndrome, and others. Here, several in-vitro and screening models demonstrate their clinical relevance. The logical goal, experimental methods, and assessment criteria of diverse screening models of diuretic action are highlighted in the current study. It also highlights the value and significance of these screening methods for determining the efficacy and safety of various members of various types of diuretic medicines. This review also revealed how some screening model improvements were successful. Studying the diuretic potential of various drugs is therefore absolutely helpful. In the end, the current review establishes a robust framework for dosage modification and fatal impact research of diverse kinds of diuretics. Thus, this study provides some suggestions for choosing cutting-edge methods to check the activity of diuretics. It also exposes the effects of the creation and adjustment of these screening methods, making them more effective in the future for assessing the diuretic potential of various diuretics agents.