Sophora interrupta bedd., ameliorates doxorubicin induced myocardial necrosis by attenuation of oxidative stress and structural cardiomyocyte alterations in rats

Abstract

The present study aimed at investigating the cardioprotective activity of Sophora interrupta Bedd against doxorubicin induced myocardial necrosis by attenuation of oxidative stress and structural cardiomyocyte alterations in rats.The experimental procedure was carried out with male Wistar rats inducing cardiotoxicity by administrating Doxorubicin in normal saline 3.750 mg/kg i.p on day 7, 14, 21 and 28 and treated with test extract of Sophora interrupta Bedd at a dose of 200 & 400 mg/kg, b.wt., per orally once daily for 28 days. The heart weight to body weight ratio was measured to evaluate the effect of extract on MI. The plasma was evaluated for the biochemical parameters and cardiac markers. Pro-oxidant & anti-oxidant levels were measured along with the histopathological examination of the heart. The test extractsSophora interrupta Bedd showed a significant (p< 0.001) restoration of the altered plasma biochemical parameters and cardiac markers reducing the extent of damage in heart musculature. The anti-oxidant effect of the test extract plays a prominent role in curative effect of cardiomyopathy associated with doxorubicin.The test extract of Sophora interrupta Bedd was beneficial for doxorubicin induced cardiotoxicity by ameliorating oxidative stress and restoring the abnormal structural changes in the heart tissue.