Formulation and evaluation of nano-ethogel of silver sulfadiazine for treatment of topical burns

Abstract

The present study deals with the formulation of ethosomal suspension containing silver sulfadiazine, followed by its incorporation into a hydrogel, leading to the formulation of a novel vesicular nano-ethogel of silver sulfadiazine for the treatment of topical burns. Silver Sulfadiazine ethosomes were prepared by the hot method suggested by Elka Touitou. This ethosomal suspension was loaded into hydrogel made of Carbopol 934 in a ratio of 1:1. Carbopol 934 was chosen as a gelling agent as it do not cause any sort of skin irritation. The nanoethosomal formulations containing SSD were evaluated for their physical appearance, pH, spreadability, viscosity, extrudability, drug content. In vitro drug release studies were performed for five hours and it was observed that the formulation F4 had the maximum amount of drug released within duration of five hours i.e. 76.80%. The complete study wrap up that this ethosomal approach of silver sulfadiazine incorporated into a hydrogel provides an advance sustained and targeted delivery of silver sulfadiazine.