Affiliation:
1. Peth-Vadgaon, Kolhapur, Maharashtra, India
2. e
Abstract
The current work focuses on the development and validation of a UV spectrophotometric technique for determining chlorpropamide in bulk and formulation. According to ICH criteria, UV spectrophotometric method was validated for a number of parameters, including linearity, precision, accuracy, sensitivity, limit of detection (LOD), and limit of quantification (LOQ). The maximum wavelength of chlorpropamide was discovered to be 580 nm, and a colorimetric method was created for the quantitative estimation of colour and to quantify the absorbance of a particular wavelength of light by a particular solution. The maximal wavelength of chlorpropamide in the complex mixture was discovered to be 710 nm. The UV spectrophotometric technique and colorimetry are simple, sensitive, accurate, repeatable, and exact. Chlorpropamide in bulk can be determined effectively using the suggested method.
Publisher
IP Innovative Publication Pvt Ltd
Subject
Applied Mathematics,General Mathematics
Reference16 articles.
1. Spectrophotometric Determination of Chlorpropamide in Bulk and Dosage Form by Complexation with Chloranilic Acid
2. Dange YD, Honmane SM, Jadge D, Bhinge SD, Salunkhe VR, Jadge DR, Development and Validation of UV-Spectrophotometric Method for Estimation of Metformin in Bulk and Tablet Dosage Form.Indian J Pharm Educ Res 2017;51(45):S754-60
3. Jani BR, Shah KV, Kapupara PP, Development and Validation of UV Spectroscopic First Derivative Method for Simultaneous Estimation of Dapagliflozin and Metformin Hydrochloride in Synthetic Mixture.J Bioequivalence Stud 2015;1(1):1-8
4. Mudassar M, Mazharoddin N, Tauseef S K, Parveen N, UV first order and second order derivative spectrophotometric method using amplitude and AUC technique for determination of sildenafil in bulk and in pharmaceutical formulation.Pharma Innov 2018;7(4):419-24
5. STABILITY INDICATING TLC-DENSITOMETRIC METHOD FOR DETERMINATION OF CHLORPROPAMIDE