Cystatin GFR better marker than creatinine GFR for accurate prediction of renal dysfunction in diabetic patients: A tertiary care centre study

Abstract

Diabetic and hypertensive patients gradually gets decreased glomerular function. Creatinine starts rising and exhibits decreased kidney function when more than 50% of glomerular function is lost. Cystatin C, a parameter which accesses kidney function accurately predicts GFR. GFR is calculated by measuring Cystatin C and Creatinine. Groups were normal patients, diabetics patients, Comparison of changes of pre and post treatment GFR by Creatinine and Cystatin. Total 57 patient studied 1) Cystatin C GFR is lower than creatinine GFR in 20 normal patients with P value with paired t test is 0.0032 hence prompts early renal evaluation whereas creatinine GFR overestimates renal function. 2) cystatin C GFR in 37 patients with kidney dysfunction and diabetes is less than Creatine GFR with p-value < 0.05 suggests more accurate prediction for renal injury. 3) Cystatin GFR is affected by age and gender 4) Change in Pre and Post treatment of 9 patients with creatinine GFR and cystatin GFR with p-value = 0.47657 > 0.05 but these patients high Creatinine levels on admission which gets normalised with remarkable rise in GFR whereas Cystatin C levels gets marginally decrease suggests renal recovery ongoing. Clearly exhibits Creatinine GFR is overestimates renal function. Patients with normal GFR by Creatinine having raised Cystatin C levels prompts early renal evaluation. Cystatin C is accurately estimating, less affected by variables and predicting severity of renal dysfunction. Thus, Cystatin C GFR better diagnostic and sensitive maker than creatinine GFR for accurate prediction of renal dysfunction in Diabetic patients.