Biochemical profile of patients in ketosis-prone diabetes state in Côte d’Ivoire

Abstract

: Diabetes keto-acidosis is the most serious hyperglycemic emergency in patients with diabetes. DKA has long been considered a key clinical feature of T1D. In this study, we assessed biochemical disorders focused on lipid and renal parameters in KPD.: We carried out a case-controls study for one year, encompassing 200 participants in total. Patients were outpatients newly diagnosed diabetics attending for the first time hospitals, controls were no-ketosis participants. Blood samples were taken, after 10 to 12 hours of fasting from the day before, in different tubes for each intended analyses according to instructor’s recommendation. The increased mean value of fasting blood glucose together with HbA1c are corrolated with ketonuria. As regard to cardio-metabolic risk, ketosis-prone patients were at greater risk than no-ketosis controls The mean AIP value was higher in KPD women than in men, with no significant statistical correlation. Uremia and creatininemia, two kidney parameters commonly prescribed to explore glomerular filtration, were correlated with some social indicators. The mean values of these both parameters increased significantly with age in KPD group. Creatinine increased significantly with age in patients, in line with glomerular filtration rate (GFR). The older the participants, the higher the mean values of these parameters. : These biochemical parameters, high atherogenic index and lower glomerular filtration rate, documented in our study, must be sought out when inaugural ketosis is suspected for improving the clinical prognosis of patients in the initial step of management.