Correlation study of CBC derivatives and biochemical prognostic marker in covid-19 patients

Abstract

: SARS-CoV2 infection induces inflammatory responses and acute lung injury in human beings. Infection causes certain haematological and biochemical changes in patients. This study aimed analyze the correlation between CBC derivatives and biochemical prognostic marker in COVID-19.: Total 80 individuals selected, 50 COVID-19 positive patients and 30 subjects negative for COVID-19 RT-PCR test. Blood collected was sent to NLR, RDW, assayed in Beckman Coulter DxH 800. Serum CRP estimated by Immuno-turbidimetric method, ferritin by CLIA. Plasma collected estimate for D-DIMER by CLIA. Unpaired T test & Pearson correlation (IBM SPSS 22.0) were used. : Elevated levels of NLR (p value <0.001), RDW (p value <0.001), FERRITIN (p value <0.001), D-D-DIMER (p value <0.001), CRP (p value <0.001) some research parameters like LHD and RSF show significant decrease. In current study the NLR positively correlate to CRP (r value=0.5, p value <0.001), NLR positively correlate to D-DIMER (r value=0.3, p value<0.05), RDW positively correlated to CRP (r value=, 0.3, p value <0.05), RDW negatively correlated to ferritin (r value=-0.439, p value <0.001)LHD negatively correlated ferritin (r value=-0.316, p value=<0.05), MAF negatively correlated to D-dimer (r value=-0.244 <0.05), MSCV positively correlated with CRP (r value=0.336, p value= <0.05).: The cytokine storm produced during covid-19 infection which inturn develop neutrophilia and lymphopenia, CRP production and also cause elevation of procoagulants &D-dimer. RDW and CRP are positively correlated they are elevated during inflammatory conditions.RDW and FERRITIN show negative correlation. Retrospective study have some limitation so future studies will reveal more information.