A cross-sectional study of thyroid profile, Anti-TPO and iron levels with uric acid of melasma cases in tertiary hospital, Bhopal

Abstract

Melasma, also called ‘chloasma’, is a common skin condition of adults in which light to dark brown or grayish pigmentation develops, mainly on the face. Although it can affect both genders and any race, it is more common in women. Melasma is an acquired pigmentary disorder described as symmetrical blotchy or splotchy hyperpigmented macules and patches. The aim of this study was to investigate thyroid profile with anti TPO and iron, uric acid level, in male and female patients. It is a cross-sectional observational study done on 76 females and 25 male who were diagnosed with melasma and thyroid profile with anti TPO, serum iron and uric acid levels were measured. In our study females were more affected then males. In females Mean ± SD value of serum TSH (5.1±2.51) and anti-TPO (11.2±3.1) levels were increased when compared to males(4.9±2.54) and (9.2±1.9). Serum iron value was low in females (83.7±30) than males (90±29). All biochemical parameter were not significant but anti TPO and FT3 showed significant (P<0.001) in female with compared to male. Serum uric acid (3.56±0.77) and serum iron (83.7±30) Mean± SD value was low in melasma females than males which is not significant. Females Mean±SD value of T3 (1.30±0.62) and T4(6.8±1.9), FT4 (1.2±0.44) were non significance showed than compared to males and not significant to males T3 (1.33±0.66) and T4(7.1±1.6), FT4 (1.3±0.67) respectively. Melasma is more severe in females than males. Thyroid profile is not the accurate parameter but anti TPO, and iron level are predictive marker of melasma.