The role of exosomal survivin in the diagnosis of breast cancer

Abstract

Breast cancer is the leading cause of death in women across the globe. The aim of this study is to compare exosomal survivin levels in breast cancer patients and healthy population. It is also to investigate the relationship between clinicopathological parameters of breast cancer and exosomal survivin levels. Patients who were diagnosed with histopathologically confirmed breast cancer and healthy volunteers were included in the study. Serum samples from patients and healthy volunteers were stored at -80℃. Exosomes were isolated from these serum samples. The integrity of the exosomes was disrupted. Survivin levels were measured by Enzyme Linked Immuno Sorbent Assay. Data on clinicopathological parameters were obtained from patient files and compared statistically.