Histopathological spectrum of nonneoplastic lesions of large intestine- A three year study

Abstract

Large intestine is a site for an array of different nonneoplastic and neoplastic lesions. Clinical manifestations may overlap, thus making the diagnosis difficult and creating the need for tissue diagnosis. Our study aims at detail histopathological examination of the different non neoplastic lesions of large intestine. A total of 30 nonneoplastic lesions of large intestine were studied over a period of 3 years. Both resected specimens and endoscopic biopsy specimens were included. Histopathological findings were studied along with analysis of the distribution of lesions and correlation of the histopathological findings with clinical parameters. The lesions were distributed in all age groups, with maximum frequency in 5 to 8 decades. The frequency was significantly higher in males (23 cases- 76.7%) as compared to females (7 cases- 23.3%). The most common lesion was perforation (10 cases), followed by gangrene (4 cases). Two cases had gangrene with perforation. Other lesions included Hirschprung’s disease (5 cases), Crohn’s disease (two cases) and one case each of Enteric duplication cyst, tuberculosis, amoebic colitis with perforation and Peutz-Jeghers polyp. Three cases had nonspecific inflammation. Our study emphasizes the importance of histopathological examination in the management of colonic lesions