Affiliation:
1. Pushpagiri Institute of Medical Sciences & Research Centre, Thiruvalla, Kerala, India
2. P
Abstract
Tulobuterol Transdermal Drug Delivery (TTD) may be beneficial in COPD management. We aimed to study the effect of adding TTD to Triple Inhalation therapy (TI). Participants on TTD and TI (TTD-TI cohort) and, TI only (TI cohort) were identified at the out-patient pharmacy counter. There was no loss to follow-up from 35 participants each enrolled in the cohorts. They were assessed with Modified British Medical Research Council questionnaire (modified Medical Research Council), COPD Control Questionnaire (CCQ) and COPD Assessment Test (CAT). The latter two were repeated at the end of six months. The change in score were compared with Mann-Whitney-U test. Mean age of participants in years was 63.4 and 65.7; 31% and 20% were females and rest were males in TTD-TI and TI cohorts respectively. All of them had modified Medical Research Council grade 2 or above. CCQ and CAT scores were comparable at baseline. Change in both CCQ and CAT scores were statistically significant between the cohorts (p<0.001). Median (minimum, maximum) change in CCQ score were -0.6(-2.8, 0) in TTD-TI cohort and 0.3(-2 to 1.2) in TI cohort. Median (minimum, maximum) change in CAT score were -4(-16, -2) in TTD-TI cohort and 2(-7 to 7) in TI cohort. All of the participants in TTD-TI cohort and, 5(14.3%) and 7(20%) participants improved in TI cohort by CCQ and CAT score respectively. There would be a subjective improvement with addition of tulobuterol transdermal patch on to triple inhalation therapy for older persons with COPD.
Publisher
IP Innovative Publication Pvt Ltd
Subject
General Materials Science
Reference17 articles.
1. Salvi S, Kumar G A, Dhaliwal R S, Paulson K, Koul K A, The burden of chronic respiratory diseases and their heterogeneity at the states of India; the Global Burden of Disease Study 1990-2016..Lancet Global Health 2018;6(12):1363-74
2. Chronic obstructive pulmonary disease (COPD). Available from URL:- http://www.who.int/news-room/fact-sheets/detail/chronic obstructive-pulmonary-disease-(copd). Last accessed 2021 on October 9..
3. Global Initiative for Chronic Obstructive Lung Disease global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease;2020. Available from URL:- http://www.goldcopd.org/. Last accessed 2021 on October 9..
4. Petite S E, What is the role of triple inhaled therapy in COPD?.JAAPA 2019;32(10):44-5
5. Al-Showair RAM, Tarsin W Y, Assi K H, Pearson S B, Chrystyn H, Can all patients with COPD use the correct inhalation flow with all inhalers and does training help.Respir Med 2007;101(11):2395-401